diff --git a/CHANGELOG.md b/CHANGELOG.md
index f390aee..52415ef 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -3,6 +3,7 @@
 * 2.3.next in progress
   * Address [#430](https://github.com/seancorfield/honeysql/issues/430) by treating `:'` as introducing a name that should be treating literally and not formatted as a SQL entity (which respects quoting, dot-splitting, etc); this effectively expands the "escape hatch" introduced via [#352](https://github.com/seancorfield/honeysql/issues/352) in 2.2.868. _Note that the function context behavior formats as a SQL entity, rather than the usual SQL "keyword", whereas this new context is a literal transcription rather than as a SQL entity!_
   * Address [#427](https://github.com/seancorfield/honeysql/issues/427) by adding `set-options!`.
+  * Address [#415](https://github.com/seancorfield/honeysql/issues/415) by supporting multiple column names in `DROP COLUMN`.
 
 * 2.3.928 -- 2022-09-04
   * Address [#425](https://github.com/seancorfield/honeysql/issues/425) by clarifying that `INTERVAL` as special syntax may be MySQL-specific and PostgreSQL uses difference syntax (because `INTERVAL` is a data type there).
diff --git a/doc/clause-reference.md b/doc/clause-reference.md
index 4289a3a..686bdfb 100644
--- a/doc/clause-reference.md
+++ b/doc/clause-reference.md
@@ -85,7 +85,8 @@ user=> (sql/format {:alter-table [:fruit
 
 As can be seen above, `:add-column` and `:alter-column`
 both accept a column description (as a sequence of simple
-expressions); `:drop-column` accepts a single column name,
+expressions); `:drop-column` accepts one or more column names
+optionally prefixed by `:if-exists`,
 and `:rename-column` accepts a sequence with two column
 names: the "from" and the "to" names.
 
diff --git a/src/honey/sql.cljc b/src/honey/sql.cljc
index 3d2746b..95ef85e 100644
--- a/src/honey/sql.cljc
+++ b/src/honey/sql.cljc
@@ -981,6 +981,32 @@
       (into [(str/join sqls)] params))
     [s]))
 
+(defn- destructure-drop-columns [tables]
+  (let [params
+        (if (sequential? tables)
+          tables
+          [tables])
+        _    (when-not (every? ident? params)
+               (throw (ex-info "DROP COLUMNS expects just column names"
+                               {:tables tables})))]
+    (loop [if-exists false coll params sqls []]
+      (if (seq coll)
+        (if (#{:if-exists 'if-exists} (first coll))
+          (recur true (rest coll) sqls)
+          (recur false (rest coll)
+                 (conj sqls (cond->> (format-entity (first coll))
+                              if-exists
+                              (str (sql-kw :if-exists) " ")))))
+        (if if-exists
+          (throw (ex-info (str "DROP COLUMNS: missing column name after IF EXISTS")
+                          {:tables tables}))
+          sqls)))))
+
+(defn- format-drop-columns
+  [k params]
+  (let [tables (destructure-drop-columns params)]
+    [(str/join ", " (mapv #(str (sql-kw k) " " %) tables))]))
+
 (defn- check-where
   "Given a formatter function, performs a pre-flight check that there is
   a non-empty where clause if at least basic checking is enabled."
@@ -1009,7 +1035,7 @@
   and removed."
   (atom {:alter-table     #'format-alter-table
          :add-column      #'format-add-item
-         :drop-column     #'format-drop-items
+         :drop-column     #'format-drop-columns
          :alter-column    (fn [k spec]
                             (format-add-item
                              (if (mysql?) :modify-column k)
diff --git a/src/honey/sql/helpers.cljc b/src/honey/sql/helpers.cljc
index a26e263..0dd99a0 100644
--- a/src/honey/sql/helpers.cljc
+++ b/src/honey/sql/helpers.cljc
@@ -172,12 +172,15 @@
   (generic :add-column col-elems))
 
 (defn drop-column
-  "Takes a single column name (use with `alter-table`).
+  "Takes one or more column names (use with `alter-table`).
 
-  (alter-table :foo (drop-column :bar))"
+  Accepts an `IF EXISTS` flag (keyword or symbol) before
+  any column names.
+
+  (alter-table :foo (drop-column :bar :if-exists :quux))"
   {:arglists '([col])}
-  [& args]
-  (generic-1 :drop-column args))
+  [& col-elems]
+  (generic :drop-column col-elems))
 
 (defn alter-column
   "Like add-column, accepts any number of SQL elements
diff --git a/test/honey/sql/helpers_test.cljc b/test/honey/sql/helpers_test.cljc
index c0d0654..37bf7f0 100644
--- a/test/honey/sql/helpers_test.cljc
+++ b/test/honey/sql/helpers_test.cljc
@@ -633,8 +633,13 @@
          ["ALTER TABLE fruit ADD COLUMN id INT NOT NULL"]))
   (is (= (sql/format (alter-table :fruit
                                   (add-column :id :int [:not nil])
-                                  (drop-column :ident)))
-         ["ALTER TABLE fruit ADD COLUMN id INT NOT NULL, DROP COLUMN ident"])))
+                                  (drop-column :ident)
+                                  (drop-column :if-exists :another)))
+         ["ALTER TABLE fruit ADD COLUMN id INT NOT NULL, DROP COLUMN ident, DROP COLUMN IF EXISTS another"]))
+  (is (= (sql/format (alter-table :fruit
+                                  (drop-column :a :b :if-exists :c :d)
+                                  (drop-column :if-exists :e)))
+         ["ALTER TABLE fruit DROP COLUMN a, DROP COLUMN b, DROP COLUMN IF EXISTS c, DROP COLUMN d, DROP COLUMN IF EXISTS e"])))
 
 (deftest issue-293-insert-into-data
   ;; insert into as (and other tests) based on :insert-into