diff --git a/CHANGELOG.md b/CHANGELOG.md
index a5903e2..76922d8 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,7 +1,8 @@
 # Changes
 
 * 2.2.next in progress
-  * Fix #380 by correcting test for function type in `register-clause!`.
+  * Address [#382](https://github.com/seancorfield/honeysql/issues/382) by adding `:case-expr` for BigQuery support.
+  * Fix [#380](https://github.com/seancorfield/honeysql/issues/380) by correcting test for function type in `register-clause!` and `register-fn!`.
 
 * 2.2.858 -- 2022-01-20
   * Address #377 by adding `honey.sql/map=` to convert a hash map into an equality condition (for a `WHERE` clause).
diff --git a/doc/special-syntax.md b/doc/special-syntax.md
index 0bfe68f..50fa7d2 100644
--- a/doc/special-syntax.md
+++ b/doc/special-syntax.md
@@ -41,6 +41,15 @@ may be `:else` (or `'else`) to produce `ELSE`, otherwise
 ;; => ["CASE WHEN a < ? THEN ? WHEN a > ? THEN ? ELSE ? END" 10 "small" 100 "big" "medium"]
 ```
 
+Google BigQuery supports a variant of `CASE` that takes an expression and then the `WHEN`
+clauses contain expressions to match against, rather than conditions. HoneySQL supports
+this using `:case-expr`:
+
+```clojure
+(sql/format-expr [:case-expr :a 10 "small" 100 "big" :else "medium"])
+;; => ["CASE a WHEN ? THEN ? WHEN ? THEN ? ELSE ? END" 10 "small" 100 "big" "medium"]
+```
+
 ## cast
 
 A SQL CAST expression. Expects an expression and something
diff --git a/src/honey/sql.cljc b/src/honey/sql.cljc
index a36e56b..b0268d1 100644
--- a/src/honey/sql.cljc
+++ b/src/honey/sql.cljc
@@ -1124,6 +1124,31 @@
                 (partition 2 pairs))]
     (into [(str/join ", " sqls)] params)))
 
+(defn- case-clauses
+  "For both :case and :case-expr."
+  [k clauses]
+  (let [case-expr? (= :case-expr k)
+        [sqlx & paramsx] (when case-expr? (format-expr (first clauses)))
+        [sqls params]
+        (reduce (fn [[sqls params] [condition value]]
+                  (let [[sqlc & paramsc] (when-not (= :else condition)
+                                           (format-expr condition))
+                        [sqlv & paramsv] (format-expr value)]
+                    [(if (or (= :else condition)
+                             (= 'else condition))
+                       (conj sqls (sql-kw :else) sqlv)
+                       (conj sqls (sql-kw :when) sqlc (sql-kw :then) sqlv))
+                     (-> params (into paramsc) (into paramsv))]))
+                [[] []]
+                (partition 2 (if case-expr? (rest clauses) clauses)))]
+    (-> [(str (sql-kw :case) " "
+              (when case-expr?
+                (str sqlx " "))
+              (str/join " " sqls)
+              " " (sql-kw :end))]
+        (into paramsx)
+        (into params))))
+
 (def ^:private special-syntax
   (atom
    {;; these "functions" are mostly used in column
@@ -1168,24 +1193,8 @@
             (into params-x)
             (into params-a)
             (into params-b))))
-    :case
-    (fn [_ clauses]
-      (let [[sqls params]
-            (reduce (fn [[sqls params] [condition value]]
-                      (let [[sqlc & paramsc] (when-not (= :else condition)
-                                               (format-expr condition))
-                            [sqlv & paramsv] (format-expr value)]
-                        [(if (or (= :else condition)
-                                 (= 'else condition))
-                           (conj sqls (sql-kw :else) sqlv)
-                           (conj sqls (sql-kw :when) sqlc (sql-kw :then) sqlv))
-                         (-> params (into paramsc) (into paramsv))]))
-                    [[] []]
-                    (partition 2 clauses))]
-        (into [(str (sql-kw :case) " "
-                    (str/join " " sqls)
-                    " " (sql-kw :end))]
-              params)))
+    :case      #'case-clauses
+    :case-expr #'case-clauses
     :cast
     (fn [_ [x type]]
       (let [[sql & params]   (format-expr x)
diff --git a/test/honey/bigquery_test.cljc b/test/honey/bigquery_test.cljc
index b117360..831c3d9 100644
--- a/test/honey/bigquery_test.cljc
+++ b/test/honey/bigquery_test.cljc
@@ -42,3 +42,13 @@
                                     {:add-column [:name :string :if-not-exists]}
                                     {:add-column [:my_struct [:bigquery/struct [:name :string] [:description :string]] :if-not-exists]}
                                     {:add-column [:my_array [:bigquery/array :string] :if-not-exists]}]}))))
+
+(deftest test-case-expr
+  (is (= ["SELECT CASE foo WHEN ? THEN ? WHEN ? THEN foo / ? ELSE ? END FROM bar"
+          1 -1 2 2 0]
+         (sut/format
+          {:select [[[:case-expr :foo
+                      1 -1
+                      2 [:/ :foo 2]
+                      :else 0]]]
+           :from [:bar]}))))